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While FMO3 inhibitors reduce TMAO levels, they risk adverse effects like hepatic inflammation, and individuals with FMO3 gene defects may develop trimethylaminuria (fish odour syndrome)

A sample size of 14 will be required to detect this change with a power of 80% and a Type 1 error of 0.05

Resting State Functional Connectivity Patterns Associated with Pharmacological Treatment Resistance in Temporal Lobe Epilepsy. Epilepsy Research 149 (November 17, 2018): 3743
