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These functions are dependent on the interplay between adult-born hippocampal cells and old granule cells and their synaptic connections with other hippocampal regions, including CA3 ( Impairment of Adult Hippocampal Neurogenesis and Affective Disorders A paradigm-shift insight is that impairment of AHN in the ventral hippocampus (VH) may affect the normal physiology of DG, contributing to affective disorders (Sahay et al., 2011a)