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Therefore, gut microbiota that exert protective effects on the intestinal mucosal barrier are crucial for human adaptation to hypertension and provide adaptive protection for the cardiovascular system in high-altitude environments

Taken together, these findings demonstrate that adipose-resident GPR146, rather than hepatic GPR146, is primarily responsible for the regulation of diet induced obesity, hepatic steatosis and circulating FFA levels in response to HFD

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Antioxidants play a crucial role in maintaining health and preventing diseases by combating oxidative stress, which arises from an imbalance between free radical generation and antioxidant levelsan imbalance that creates a favorable environment for prooxidants (Li et al., 2025)