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Upon conjugation with glutathione, the selectivity index of epothilone towards the tumor cell lines was increased by about 5.7 folds, ensuring their higher solubility, facilitating the penetration of the drugs across the plasma membrane via the ATP-Binding Cassette (ABC) proteins ABCC1 that called GSH-S-conjugate pump [6, 41, 53, 78]
340 Mutations in the E3 ubiquitin ligase TRIAD3A, which facilitates the autophagic removal of tau, have been associated with neurodegenerative disorders such as HD and exacerbate tau aggregation and propagation in a mouse model
[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Mohseni R, ArabSadeghabadi Z, Ziamajidi N, Abbasalipourkabir R, RezaeiFarimani A
