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Apart from these shared features, other genetic alterations, such as the loss of PTEN , NOTCH receptors and the CREB binding protein, are also observed and the importance of these defects has been functionally validated in vivo and in vitro [126]
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By contrast, when EpoB was administered immediately following axotomy, using the same concentration range as in a previous mouse study (approximately 1 nM) and corresponding to concentrations administrated to patients with breast cancer 20,25 , visible regeneration was observed following a latency period lasting approximately 10 min (66% regenerated, 24% stalled, n = 29

The FDA has published a briefing document evaluating BPC-157 in the context of ulcerative colitis
