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Studies evaluating transient elastography have demonstrated reproducible performance across a variety of patient populations, including persons with HCV.[14,15,16] Transient elastography is generally considered to be the most accurate noninvasive testing for liver fibrosis in patients with chronic HCV and a patient should be presumed to have cirrhosis if they have a FibroScan stiffness score greater than 12.5 kPa.[4,16] The FibroScan also performs a controlled attenuation parameter (CAP) measurement that estimates the amount of fat in the liver

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Dysbiosis impairs the intestinal barrier, increasing its permeability and allowing bacteria and lipopolysaccharides (LPS) from the gut to translocate into the systemic circulation, leading to systemic inflammation (148)

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