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Meta-analyses show berberine reduces body weight by approximately 2-3 kg (4.5-6.5 pounds) over 12-16 weeks, with improvements in fasting blood glucose, insulin sensitivity, and lipid profiles

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Furthermore, potential risks of immune-modulating treatment during pregnancy are not specific to FcRn antagonists, as illustrated by the need for patients with TED to stop treatment with corticosteroids and anti-thyroid drugs when planning a pregnancy [344]