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To map the prominence of organ cross-talk studies, we searched PubMed (20152025) via paired organ terms with keywords such as cross-talk, axis, or network, identifying 50,523 relevant articles

Inflammation reduction: It supports antioxidant enzymes that calm the inflammation that drives visible aging

Current treatment options include approved drugs such as serotonin-norepinephrine reuptake inhibitors, e.g., duloxetine, gabapentinoids such as pregabalin and gabapentin, topical treatment with capsaicin, and several off-label use drugs such as other antidepressants (e.g., tricyclic antidepressants), antiepileptic drugs, and weak and strong opioids

Famurewa AC, Asogwa NT, Ezea SC (2023) Antidiabetic drug sitagliptin blocks cyclophosphamide cerebral neurotoxicity by activating Nrf2 and suppressing redox cycle imbalance, inflammatory iNOS/NO/NF-B response and caspase-3/Bax activation in rats