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Due to the non-apoptotic nature of ferroptosis, ferroptosis-based cancer treatments are expected to bypass the shortcomings of traditional therapies mediated by apoptotic pathways [225]

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A phase 1 study on forty-seven recurrent high-grade glioma patients showed reasonable safety and promising efficacy, with 40% having SD ( 6 -methylguanine-DNA methyltransferase (MGMT) promoter unmethylated nGB showed encouraging survival data with median PFS and OS of 8.6 months and 15.7 months, respectively ( Buparlisib, a pan-PI3K inhibitor, has been the focus of several clinical trials in GB

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