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Also, in models of depression and anxiety disorders, the excitatoryinhibitory imbalance caused by astrocyte dysfunction has been implicated as an important pathogenic factor (Zhou et al., 2019)

Research has examined DSIP's effects on circadian rhythm regulation, its interactions with the hypothalamic-pituitary axis, and its potential influence on cortisol and ACTH levels during stress responses

Some patients come in for a one-time boost during illness or high stress

Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model