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When activated, Nrf2 dissociates from the cytosolic protein, Keap1 (Kelch-like ECH associated protein 1), and translocates to the nucleus to bind to AREs in the promoter/enhancer portion of genes associated with phase II detoxification and antioxidant enzyme genes [150] (Figure 1)
Taking collagen on an empty stomach is often recommended because it prevents the collagen peptides from competing with other food proteins for absorption
Animal models of HHcy corroborate these findings
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