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While some patients experience excellent, long-lasting relief after a single ultrasound-guided injection, a standard treatment regimen often consists of 1 to 3 injections spaced about 3 to 6 weeks apart

This is particularly important as elderly populations are rising rapidly, and ageing-related diseases are predicted to cause a great deal of societal and economic burden in the coming decades

This dysfunction is caused by several factors, including vagal dysfunction, impaired activity of interstitial cells of Cajal (ICC), reduced neural nitric oxide synthase activity, and increased oxidative stress[101]