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Functional analysis demonstrated that miR-491-5p overexpression exerted a tumor suppressor effect by targeting IGF2, and this was also confirmed by the negative correlation between miRNA levels and IGF2 mRNA and protein levels in CRC tissues and cell lines

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These were induced with permanent major vessel occlusions, central [38,39] and peripheral [40,41,42,43,44,45,46], similar noxious procedures [47,48,49,50], and agents applications [51,52,53,54,55,56]