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boosting acetylcholine provides substrate for learning Caution: Acetylcholinesterase inhibitors were noted to reduce fosgonimeton efficacy in clinical trials (ACT-AD finding), suggesting potential interference Unknown interaction: Dihexa + cholinergics have not been formally studied Modafinil Some stacking discussions mention modafinil (a eugeroic/wakefulness-promoting agent): Rationale: Addresses alertness while Dihexa targets learning and neuroprotection Interaction risk: Both affect dopamine and executive function

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doi: 10.1016/S2213-2600(17)30353-3 201 AntoniaSJVillegasADanielDVicenteDMurakamiSHuiRet al