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The essential tool (i.e., targeting NOs cytotoxic and damaging actions but not interfering with its essential protective functions and even promoting them) can be implemented [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]

Figure 4 6 Clinical translation prospects and future research directions With the growing understanding of the critical roles of regulated cell death (RCD) pathways in modulating antitumor immunity and overcoming immune checkpoint inhibitor (ICI) resistance, translating preclinical findings into effective clinical strategies has become a central focus in melanoma research (168)

Basal ganglia are known as the high iron content region in the brain 25 , and the elevation of iron deposition in basal ganglia is related to the normal aging process 26

Synergy Research Centers, a trusted clinical research institution based in San Diego, has been conducting inpatient and outpatient clinical trials for over 24 years