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Obesity and metabolic disease carry particular health burdens for men, including increased risk of type 2 diabetes, cardiovascular disease, obstructive sleep apnoea, and hypogonadism (low testosterone)

New or worsening neurological symptoms such as paraesthesia or gait disturbance require same-day clinical assessment and prompt parenteral B12 treatment per BSH guidance

It resists degradation for much longer than the acetate version, making it more robust for longer-term experiments or situations where refrigeration might be inconsistent

in the case of diseases, every treatment should be consulted with a doctor