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Larsen JM

Indeed, a recent review highlights a potential signaling cascade involving NF-B, p38 and nitric oxide in which cannabinoids prevent the release of glutamate from hemichannels (Labra et al., 2018)

More recently, a randomized, double-blind, 24-week cross-over trial in 63 adults suffering from migraines found that 500 mg/day of magnesium oxide was equally effective as sodium valproate for reducing the migraine frequency and duration over the eight-week treatment period (194)

For skin specifically, this matters because the accumulation of senescent fibroblasts in aging dermis is one of the primary drivers of collagen loss