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Ferroptosis in cardiovascular diseases: current status, challenges, and future perspectives

In diabetic state, hyperglycemia and AGEs can inhibit the activation of AMPK, reduce glucose uptake, induce endothelial cells to differentiate into mesenchymal cells, and destroy the normal structure of vascular endothelial cells

Together, they build a fibrocartilaginous bridge across the fracture gap called a soft callus

This conclusion is based on the findings from a six-month randomized, double-blinded, placebo-controlled trial involving 54 non-smoking adults who were assigned to receive either a placebo, 250 mg/day of GSH, or 1000 mg/day of GSH