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Although we initially assumed that oxygen may enhance glutamate production by activating the TCA cycle to increase the supply of 2-OG, greater air availability did not promote 2-OG production by the CgCS+CitS strain (Figs

To enhance interpretability despite this variability, we pooled outcomes within instruments (HDRS, BDI, MADRS), conducted prespecified subgroup analyses by comparator group and age, used random-effects models, performed leave-one-out sensitivity analyses and publication-bias diagnostics, and applied meta-regression to examine treatment duration and daily dose

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Syringes and needles are permitted when accompanied by the medication they are intended for