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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Ni XP, Butler AA, Cone RD, Humphreys MH

Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes

These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane

Insulin-like growth factors and their binding proteins before and after weight loss and their associations with hormonal and metabolic parameters in obese adolescent girls