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Landmark studies, such as the COMBO-DN trial, have surprisingly indicated that certain combination regimens did not significantly outperform high-dose monotherapy in terms of pain reduction

However, the mechanisms of action for some inhibitors are not yet fully understood, and there are potential risks that remain unknown

Current findings remain preliminary and exploratory, requiring further research for clarification

GPX4 is present in the cytosol, mitochondria and nucleus of cells in the testes, spermatozoa and brain [17]
