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(54) PATHOPHYSIOLOGY OF ALCOHOL AND CIRRHOSIS Acetaldehyde is a metabolite of alcohol that, when it accumulates, produces liver damage as the result of its ability to generate formation of DNA adducts such as sites without purine or pyrimidine (Figure 3)

Results were normalized to housekeeping genes ( GAPDH ) and expressed as a fold change from control treatments using the Ct threshold cycle method of normalization

Robust study design and knowledge sharing must be prioritized by both funding institutions and clinician-researchers

Glutathione is a relatively large molecule, which makes it difficult for it to pass through the outer layers of the skin to reach the deeper levels where it can do the most good