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Senescence is characterized by a stable cell cycle arrest and multiple phenotypic changes, including the secretion of a wide array of pro-inflammatory cytokines, proteases, and other factors collectively known as the senescence-associated secretory phenotype (SASP) ( As several of the changes associated with senescence can also be observed in other cellular states, proper identification of cellular senescence requires the presence of multiple hallmarks

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Social relationships and health: the toxic effects of perceived social isolation