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The trial duration and LC dosage were heterogeneous, which may have affected the outcomes

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As shown in Figure 3 A and C, the sample distribution pattern in the scores plot showed both control group and NLF group have a clear separation from ALF group, indicating that the ACs profile of the ALF children was significantly different from that of the other two groups

So, TMAO can play an essential role in regulating inflammation and result in protective or causative effects, stimulating or attenuating the production of inflammatory cytokines that can attract more immune cells, forming a vicious circle that leads to foam cells formation and atherosclerosis development (81)