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Description
Only two forms of B12 are active as a coenzyme in the body: Methylcobalamin and adenosylcobalamin are the active coenzyme forms of B12
At the molecular level, reduced NNMT activity shifts cellular methylation patterns, potentially altering epigenetic modifications via changes in SAM/S-adenosylhomocysteine (SAH) ratios
Lack of response may indicate incorrect diagnosis, concurrent deficiencies, or inadequate treatment frequency
Andres E, Federici L, Affenberger S, Vidal-Alaball J, Loukili NH, Zimmer J, et al: B12 deficiency: a look beyond pernicious anemia
