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Chromatin remodeling factors, such as HELLS, suppress ferroptosis by altering the expression of lipid metabolism genes like SCD and FADS2, which regulate monounsaturated fatty acid (MUFA) synthesis to counteract lipid peroxidation [81,82,83]

In this process, the phenolic hydroxyl group on one benzene ring of Tyrosine is oxidized to generate DOPAquinone

Overman MJ, Yothers G, Puhalla SL, Sanoff HK, Cohen DJ, Guthrie KA, Ganz PA, Kopetz S , Lucas PC, Blanke CD, Jacobs SA, Hong TS, Wolmark N, Hochster HS, George TJ, Lima CM

Any stress, be it physical or mental, orthostatic, emotional, sensory or cognitive, places increased demands on local brain perfusion, which in ME/CFS patients may not be adequately matched with requirements due to a dysfunctional NVC