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1 Introduction Parkinsons disease (PD) has been accepted to be the second most common neurodegenerative disease worldwide after Alzheimers disease (AD), with Alpha-synuclein ( -Syn) deposition being its primary pathological manifestation

Recent studies have raised concerns with the validity of a binary M1/M2 model for macrophage polarization states, especially in vivo, and several studies argue that true phenotypes lie along a spectrum from proinflammatory to anti-inflammatory and that some states can even simultaneously possess features from both ends of the spectrum depending on context
