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Higher resting cerebrovascular tone may occur due to endothelial dysfunction (Willie et al., 2014), as seen in cardiovascular disease (Jay Widmer and Lerman, 2014
doi: 10.1186/s12958-018-0436-9
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It can be used as an effective anti-cancer drug on its own or in combination with other drugs to inhibit tumor cell growth by influencing different signaling pathways and molecular targets involved in the development of multiple cancers (Giordano and Tommonaro, 2019)
