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Lastly, the occurrence of CRC or other LS-associated malignancies in at least two first- or second-degree relatives (including grandparents, aunts, uncles, nephews, nieces, or grandchildren) at any age provides further justification for comprehensive genetic evaluation to identify hereditary cancer risks ( TGF-R2 , BAX , and PTEN

doi: 10.1080/01616412.2016.1251711

If a patient develops skin rash, fever, leukopenia or any sign of an adverse reaction, reevaluate benefit-risk of continuing therapy or re-challenge with sulfamethoxazole and trimethoprim injection [see Warnings and Precautions (5.2)]

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