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Another study using NR supplementation showed that doses up to 1000 mg per day for 10 weeks were well tolerated in patients affected by mild cognitive impairments (MCI) 246

Using this compound as a marker of cobalamin deficiency, we have been able to demonstrate that cats and dogs with very low serum cobalamin do indeed have a significant tissue-level cobalamin deficiency (Figure 2)

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Honestly, though, this is one area where cutting corners can lead to catastrophic experimental failure