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Several mechanisms have been proposed, including effects on plasma membrane Ca 2 + pumps (Tsokos-Kuhn, 1989), which can lead to Ca 2 + -induced DNA damage (Ray et al ., 1990), mito-chondrial damage (Meyers et al ., 1988) resulting in glutathione depletion and oxidative stress (Jaeschke, 1990) and apoptosis (Ray et al ., 1996)
In agreement with these data, ferrichrome , a Lactobacillus casei -derived siderophore, activated TLR4 signaling in TAMs, leading to a pro-inflammatory program that increased CD8 + T cell infiltration and improved anti-PD-L1 therapy in PDAC [112]
Brain injury , 30 (7), 908-913
Cordella L
