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Based on this the use of phosphate buffer, pH 7.4, was suggested by Silk et al to reduce the undesirable non-enzymic hydrolysis to negligible proportions despite of a pH optimum of 8.5 26

One clinical study investigated the effects of NR supplementation on skeletal muscle in 12 healthy elderlies 314

Huber et al

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives
