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In people with reduced ALDH2 levels (and thus more acetaldehyde), alcohol is more likely to induce asthma.[ref] One study explains: Impaired ALDH2 activity leads to high peak levels of acetaldehyde and to histamine release. Studies show that inhaling acetaldehyde induces histamine-mediated airway constriction, such as is seen in asthma.[ref] Hangovers and histamine A recent animal study sheds light on the age-old question of what causes hangover symptoms

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doi: 10.1186/s12944-017-0613-4, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 56.Bugianesi E, Manzini P, D'Antico S, Vanni E, Longo F, Leone N, et al