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doi: 10.3390/IJMS24087473 166 SolenskyR

[66,67] During melanogenesis, tyrosinase is responsible for the conversion of L-tyrosine to L-DOPA and subsequently to dopa-quinone, then the pathway bifurcates to produce eumelanin or phaeomelanin
Hold the syringe at a 45-degree or 90-degree angle (this depends on the length of the needle and fat thickness)

No study has tested these three together in animals or humans, so the synergy is reasoned from mechanism, not measured