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Study design: hormone-manipulation protocol Throughout the six-month protocol, each participant received monthly injections of the GnRH agonist depot leuprolide acetate (Lupron, 3.75 mg IM), which suppresses the ovarian secretion of estradiol and progesterone
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The problem with hCG booster shots is that they increase the risk of ovarian hyperstimulation syndrome (OHSS)

Nikitovic, Bojana