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Its a story of immense promise that ultimately fell short of the specific, rigorous endpoints required for a commercial drug

Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms

breastfeeding Information regarding the use of Optineuron Injection during breastfeeding is not available

They typically contain cortisone combined with a local anesthetic