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doi: 10.1038/nm.4256

As concern the first, the cathepsin-mediated cell death, our data are in line with those provided by other authors, demonstrating that inhibitors of autophagy, i.e., CQ and the phytochemical thymoquinone, could mediate lysosome permeability, resulting in leakage of cathepsin B into the cytosol where it can act as mediator of cell death 47

The biology is plausible and the animal data is intriguing, but Epithalon currently sits in the category of compelling preclinical evidence awaiting rigorous human validation

4 Concluding remarks and future directions In summary, we have provided an overview of the effects of environmental toxicants on oogenesis and female fertility