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PSC quiescence and ECM reduction in vitro The metabolic crosstalk between PDAC cells and PSC leads to the overactivation of the NF-B signaling pathway, which induces stroma remodeling and PDAC progression 27
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302 In addition, H 2 O 2 directly activates AMPK in HEK-293 cells by oxidatively modifying Cys299 and Cys304 of the AMPK subunit 303 (Table 1, Fig
