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sUA inhibits nuclear translocation of GLUT-4 in macrophages and blocks insulin IRS2/PI3K/AKT signaling

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91-94 A trial in 89 women with PCOS and insulin resistance found that berberine, in combination with hormone treatment, improved lipid profiles and SHBG levels, as well as glucose metabolism and waist circumference compared with combinations of either metformin or placebo and the same hormone treatment

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2018;3(3) doi: 10.1002/14651858.CD011044.pub2

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