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This concept is known as bioavailability

Abstract It is likely that Bladder Pain Syndrome (BPS) has a multifactorial etiology that may act predominantly through one or more pathways resulting in the typical symptom complex

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Perineal anastomotic repair is the surgical technique of choice, but a combined abdominoperineal approach would be necessary in rare cases of concomitant bladder neck injury, rectourethral fistula, multiple prior attempts to repair, or long distance between proximal and distal urethral stumps [294, 295]