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In animal models of I/R injury, curcumin has been shown to attenuate BBB breakdown and improve cognitive function, suggesting its potential as a neuroprotective agent in BBB-related disorders (Wang et al., 2019

[DOI] [PubMed] [Google Scholar] 20.Hayes P.C., Bouchier I.A., Beckett G.J

CAFs secrete cytokines such as TGF-, IL-6, and CXCL12, which enhance CSC proliferation, maintain stemness, drive EMT, and facilitate tumor invasion and metastasis

For instance, in rapidly proliferating cells where there is a high demand for nucleotides, the non-oxidative phase becomes particularly active, ensuring a steady supply of ribose-5-phosphate