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Vitamin E reduced phospholipidosis in cultured human skin fibroblasts chronically exposed to amiodarone and desethylamiodarone (DEA) and inhibited cumulative uptake of the drugs in a dose-dependent manner (102)

Department of Agriculture (USDA) and the Food and Drug Administration (FDA) recommend that healthy adults can consume up to 400 mg of caffeine per day, or 5~6 mg/kg body weight for a 65 kg individual, which does not substantially increase the risk of these diseases in healthy persons [274,275]

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