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The reasons are structural and biochemical, not just theoretical
and Available online at: and (Accessed March 23, 2024)

72,73 In addition, liposomes are nanoparticles capable of encapsulating both lipid-soluble and water-soluble drugs

Yu, H.T., Ding, X.L., Li, N., Zhang, X.Y., Zeng, X.F., Wang, S., et al., J
