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However, for nebulized antibiotics the interpretation of the antibiogram should take into consideration that, through this form of delivery, antibiotic achieves much higher concentrations in the bronchial mucosa overcoming the mechanisms of resistance.77 The persistence of bacteria despite aggressive treatment is thought to be due to several factors such as poor penetration of antibiotics into purulent airway secretions, native or acquired antibiotic resistance and production of biofilms by the bacteria that may render antibiotics ineffective or interfere with host defences

For instance, MM-151 is an oligoclonal combination of three fully human mAbs (P1X, P2X, and P3X) targeted against distinct, nonoverlapping epitopes on EGFR that overcomes signal amplification driven by both low- and high-affinity EGFR ligands (Kearns et al., 2015)

Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles

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