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Emerging research suggests that disturbances in BA metabolism not only exacerbate metabolic imbalance but also promote ferroptosis via lipid peroxidation

Tirzepatide's half-life is approximately 5 days, so the acute metabolic response occurs within 48 hours post-injection as gastric emptying slows and satiety signals intensify

The authors also thank Traci Raley, MS, ELS, from Liwen Bianji (Edanz) (www.liwenbianji.cn) for editing a draft of this manuscript
