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Neuroimaging studies in individuals with mild cognitive impairment (MCI) and early AD have shown destruction of the BBB in the hippocampus and several regions of the gray and white matter of the brain [80]

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Hence, as expected, the DRI-K28E mutant leads to a larger stability of the hybrid fibrils than when wild type DRI-A 42 are inserted, and for the 6-L:1D and 3-L:1-D:3-L models the stability is comparable to the pure L-fibrils
