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This underscores the necessity for further research to better understand the efficacy of these interventions and establish clear recommendations for their clinical application [144,147]

1,340 The rise in cAMP further activates PKA, which can inhibit the NF-B signaling pathway, reducing the production of inflammatory factors such as iNOS and other inflammation-related proteins

10.1016/B978-0-12-818006-8.00001-3 19.Wu B-K, Chen Q-H, Pan D et al (2021) A novel therapeutic strategy for hepatocellular carcinoma: immunomodulatory mechanisms of selenium and/or selenoproteins on a shift towards anti-cancer