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Cell-sorted studies have revealed widespread methylation shifts in T cells and monocytes, including reproducible changes in CD8+ T cells and distinct profiles relative to CD4+ subsets, indicative of compartment-specific immune methylome remodeling (138-141)
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Likewise, in the case of TNBC, immune-related processes such as interferon signaling and antigen presentation have been observed (285), laying the groundwork for ongoing immunotherapy
Retrieved June 8, 2025, from Institute of Medicine
