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Specifically, CAR T cells in the day 28 BM of LTR had significantly higher expression of mTOR, pS6, pAKT (mTOR and pAKT pathways) and the metabolic sensor AMPK, as well as significant increases in the fermentative glycolysis enzyme LDHA, the endogenous fatty acid metabolism enzymes SCD1, LAL, and CD45RA, suggesting an effector immunometabolic phenotype

It varies based on individual factors, such as the cause and severity of the deficiency

[DOI] [PubMed] [Google Scholar] 148.Youseflu S., Sadatmahalleh S.J., Mottaghi A., Kazemnejad A