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The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment
This has also shown potential benefit when used in combination with other immunotherapies because it results in a reduction of pathological inflammation without generalized suppression of the immune system or compromising the bodys adaptive immune response
Oxidative stress and pulmonary fibrosis
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